Searchable abstracts of presentations at key conferences in endocrinology

ea0094p262 | Reproductive Endocrinology | SFEBES2023

Sex affects Ca2+ channel expression of adult inguinal fat adipocytes and their Ca2+ response to oxytocin: Roles in mammogenesis and function?

Smith Paul , Toledo-rodriguez Maria , Fedorenko Olena

Inguinal subcutaneous fat, the site of murine mammary glands 4 and 5, is a suitable model of mammary white fat adipose tissue (WAT). WAT requires extracellular Ca2+ influx for differentiation and expansion; this primarily occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). Whereas the neuropeptide oxytocin can mobilise intracellular Ca2+ in WAT which has key roles in lactation. Our aim was to use a combination of molecular biolog...